in vivo antidiabetic and acute toxicity of spray-dried

In vivo Assessment of Antidiabetic and Antioxidant

Determination of acute toxicity (LD 50): An attempt was made to determine LD 50 of 70% hydro-ethanolic extract of Blumea balsamifera At the end of the treatment period there was no lethality or toxic reaction at the dose of 3000 mg kg-1 for which it was considered as the cut off dose

Antidiabetic activity and phytochemical screening of

May 02 2017Acute toxicity test The acute toxicity study showed that the administration of graded doses of both the aqueous and 70% ethanol extracts of A remota did not generate any observable signs of toxicity up to the dose of 5000 mg/kg which is consistent with Debela et al 2005 [] and Hailu and Engidawork 2014 reports [] This was confirmed by the absence of

In vivo assessment of antidiabetic and antioxidative

In vivo assessment of antidiabetic and antioxidative activity of natural signs of toxicity (such as writhing gasping palpitation and decreased respiratory rate) Statistical analysis Acute treatment Table 1 shows antihyperglycemic effect of FIIc in dia-

Biological activity of Bauhinia racemosa against Diabetes

Mar 08 2017Acute toxicity study An acute toxicity study revealed that BR extract did not produce any toxic sign and symptoms even no any mortality when administered per orally to rats at a dose up to 2000 mg/kg According to the dose safety level upto 2000 mg/kg two doses of BR extract i e 250 and 500 mg/kg were selected for in-vivo antidiabetic study

In Vivo hepatoprotective and antidiabetic activities of

Acute oral toxicity: Acute oral toxicity of all essential oils was carried out adopting "up and down procedure" as per given in the OECD guidelines Anonymous 5 Four groups each of rabbits and rats were formed separately having 5 animals each Weights of overnight fasting animals were taken and an oral dose of each essential oil

Antidiabetic‎ Activity of Terfezia Claveryi An In Vitro

In Vivo Anti-Diabetic Model Acute Toxicity Testing Acute toxicity testing was performed for T claveryi total methanol extract were studied where the rats took ascending oral doses up to 2000 mg/kg of each extract and signs and symptoms of toxicity were observed for the next 48 h 17 Induction of Diabetes

A sub

A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide cerium oxide silver nanoparticles and Momordica charantia in streptozotocin-induced diabetic Wistar rats† Kalakotla Shanker * a Jayarambabu Naradala b G Krishna Mohan a G S Kumar c and P L Pravallika a a Centre for Pharmaceutical Sciences Institute of Science and

In vivo antidiabetic and acute toxicity of spray

Moreover mice appeared to be normal and no mortality was observed in the acute toxicity study after treated with up to 5000mg/kg of extract These results indicated that the spray-dried Vernonia amygdalina water extract was a potential antidiabetic agent which does not induce hypoglycemic and acute toxicity on normal subject

In vivo Antidiabetic and Antioxidant Potential of

Acute toxicity testing Acute toxicity testing was performed for both ethanol and aqueous extracts following the Organization for Economic Cooperation and Development (OECD) guidelines-420 fixed dose procedure where a fixed dose level of extracts starting from 50 100 200 500 1000 increasing up to 2000 mg/kg body weight was given and signs and symptoms of toxicity

Antidiabetic Potential of Polyherbal Formulation DB14201

Feb 02 2017Preclinical efficacy studies in animal models proved the anti-diabetic potential of the extract The preclinical acute dose toxicity study and 90-days repeated dose toxicity study of DB14201 extract in wistar rats by oral route indicated

Formulation and in vivo evaluation of sodium alendronate

Spray-dried powders for lung delivery of sodium alendronate (SA) were prepared from hydroalcoholic solutions Formulations display geometric particle size below to 12 μm and spherical shape associated to a hollow structure The addition of leucine and ammonium bicarbonate leads to porous particles with rough surfaces


Acute toxicity study of the methanolic leaf extract of the plant was greater than 5000mg/kg when administered via the oral route The fasting blood glucose concentration of the animals was determined at day 0 then at day 1 4 and 7 post administration


Acute toxicity study: Acute toxicity study Wistar mice (n = 6) of either selected by random sampling technique They were used for acute toxicity study The animals were kept fasting for overnight providing only water after which the herbal extract mixture was administered orally at initial dose level of 2000 mg/kg body weight

Acute Oral Toxicity and Genotoxicity of Polysaccharide

Therefore in this study the in vivo acute toxicity and in vitro genotoxicity of BLE0 were evaluated to establish preliminary safety data to enable the development of health-functional foods derived from BLE0 2 Materials and Methods 2 1 Preparation of BLE0 Pilot-scale manufactured BLE0 was obtained from young barley leaves according to a

Acute Hypoglycemic and Antidiabetic Effect of Teuhetenone

molecules Article Acute Hypoglycemic and Antidiabetic Effect of Teuhetenone A Isolated from Turnera diffusa Ada Parra-Naranjo 1 † Cecilia Delgado-Montemayor 1 † Alejandra Fraga-Lpez 1 Gabriela Castaeda-Corral 2 Ricardo Salazar-Aranda 1 Juan Jos Acevedo-Fernndez 2 and Noemi Waksman 1 * 1 Departmento de Qumica Analtica Facultad de Medicina Universidad

In Vitro And In Vivo Evaluation Of The Antidiabetic Effect

Jul 01 2010Toxicity studies: Four main groups of male Wister albino rats were selected to study the acute toxicity of all plant extracts under investigation Each main group was subdivided to 4 subgroups (6 rats each) All groups received one oral dose of 100 300 500 and 1000mg of plant extract/kg body weight After 24 hours there

In vivo Antidiabetic and Antioxidant Potential of

In vivo Antidiabetic and Antioxidant Potential of Stephania hernandifolia in Streptozotocin-Induced-Diabetic Rats Sharma U Sahu RK1 Acute toxicity testing Acute toxicity testing was performed for both ethanol and aqueous extracts following the Organization for Economic Cooperation and Development (OECD) guidelines-420

In Vivo Subacute Toxicity and Antidiabetic Effect of

Context Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes Objective To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect Methods 5 AqE NS doses (2 6 4 21 33 and 60 g/Kg) were daily administered to mice by gavage

Evaluation of antidiabetic effect of total calystegines

Study design: Calystegines extracted from Hyoscyamys albus seeds were tested for teir acute oral toxicity and investigated for their in-vivo antidiabetic effect on Streptozotocine induced diabetes in mice Methodes: Calystegines were extracted from the seeds plant using an Ion exchange column the remaining extract was then administrated orally

Smallanthus macroscyphus: a new source of antidiabetic

In vivo acute toxicity studies were performed in adult Wistar rats There were no deaths or signs of toxicity observed after oral administration of decoction or polymatin A at any dose level up to the highest dose tested (14 0 g /kg and 2 8 g /kg respectively)

Acute toxicity studies of metformin microspheres prepared

Acute toxicity studies of metformin microspheres prepared by two different methods Metformin hydrochloride (MTF) is an antidiabetic drug used to treat Non-insulin dependent diabetic mellitus NIDDM [3] and is indicated as an adjunct to diet to lower blood glucose in cases where hyperglycemia cannot be the in-vivo studies of the prepared

Antidiabetic activity of Thespesia Populnea bark and leaf

extract of the bark and leaf In acute toxicity study the ethanolic extract ofThespesia populnea bark and leaf did not produced lethality up to the dose level of 2000 mg/kg In the antidiabetic activity the blood sugar levels were measured in First to Six groups of experimental rats in initial and at the 5 10 and 15 days of treatments are

Cytotoxicity and Oral Acute Toxicity Studies of Litsea

Materials and Methods: In vitro cytotoxicity of BEE was measured against breast adenocarcinoma prostate and colon carcinoma cell lines In the acute toxicity tests rats received oral doses of BEE as 1000 2000 and 3000 mg/kg body weight Mortality signs of toxicity body weight food consumption and gross findings were observed for 14 days

In vivo antimalarial and acute toxicity properties of

In vivo antimalarial and acute toxicity properties of hexane and chloroform extracts from Clausena anisata (Willd ) Benth Malaria is a disease caused by Plasmodium parasites and though preventable and curable is still one of the greatest global public health problems especially in sub- Saharan Africa

In vivo and in vitro antidiabetic potentials of methanol

Methods: The present study was designed to evaluate the acute and chronic effects of the methanol extract of T pumila (TPME- Methanol extract of Tephrosia pumila) against alloxan-induced diabetes in rats For acute study oral glucose tolerance test (OGTT) was performed to check the ability of the TPME to utilize oral glucose load and the chronic study of 21 days was

In vitro and in vivo antidiabetic activity of Polyalthia

Thw leaves and in vivo antidiabetic activity against streptozotocin-induced type 1 diabetes mellitus in rats In vitro studies were performed using α-amylase and α-glucosidase enzymes followed by enzyme kinetics using Lineweaver-Burk plot analysis Acute toxicity studies were performed as per OECD guidelines 423

Safety efficacy and toxicological evaluation of a novel

AbstractSafety and anti-diabetic efficacy of a novel proprietary Trigonella foenum-graecum seed extract [novel fenugreek extract (FE) Fenfuro™ CR0010810) enriched in furostanolic saponins (60% w/w HPLC) were assessed Concerning safety we undertook studies dealing with acute oral toxicity 28-d sub-chronic toxicity and Ames' bacterial reverse mutation assay that revealed no toxicity